The role of endothelial autocrine NRG1/ERBB4 signaling in cardiac remodeling
Lindsey Dugaucquier, Eline Feyen, Ligia Mateiu, Tine Bruyns, Gilles W. De Keulenaer, Vincent F. M. Segers
Abstract
The role of NRG1/ERBB signaling in endothelial cells is not completely understood. Our study contributes to the understanding of spatiotemporal heterogeneity of myocardial autocrine and paracrine responses following cardiac injury and shows a role of endothelial autocrine NRG1/ERBB4 signaling in the modulation of hypertrophic and fibrotic responses during early cardiac remodeling.
Topics & Concepts
Autocrine signallingParacrine signallingERBB4Signal transductionNeuregulinCell biologyMedicineInternal medicineBiologyReceptorReceptor tyrosine kinaseCardiac Fibrosis and RemodelingSignaling Pathways in DiseaseCardiovascular Function and Risk Factors