N-Heterocyclic carbene-catalyzed radical ring-opening acylation of oxime esters with aldehydes
Zhihao Zhang, Xin Zou, Zhenjiang Li, Yu Gao, Yuanyuan Qu, Yusheng Quan, Yi Zhou, Jinlan Li, Jie Sun, Kai Guo
Abstract
We report a radical cross-coupling of cycloketone oxime esters with aldehydes by N-heterocyclic carbene (NHC) organocatalysis. This protocol features easy operation, with no need for external redox reagent, and a broad functional group compatibility.
Topics & Concepts
ChemistryCarbeneOximeAcylationReagentCatalysisOrganocatalysisOrganic chemistryRing (chemistry)Medicinal chemistryCombinatorial chemistryEnantioselective synthesisN-Heterocyclic Carbenes in Organic and Inorganic ChemistryCatalytic Cross-Coupling ReactionsCatalytic C–H Functionalization Methods