New 1,2,4-triazole/pyrazole hybrids linked to oxime moiety as nitric oxide donor celecoxib analogs: Synthesis, cyclooxygenase inhibition anti-inflammatory, ulcerogenicity, anti-proliferative activities, apoptosis, molecular modeling and nitric oxide release studies
Wael A. A. Fadaly, Yaseen A. M. M. Elshaier, Emad H. M. Hassanein, Khaled R.A. Abdellatif
Topics & Concepts
ChemistryCelecoxibMoietyPyrazoleStereochemistryCyclooxygenasePharmacophoreBiochemistryEnzymeInflammatory mediators and NSAID effectsSynthesis and biological activitySynthesis and Biological Evaluation