Selective Cyclized α-Melanocyte-Stimulating Hormone Derivative with Multiple <i>N</i>-Methylations for Melanoma Imaging with Positron Emission Tomography
Chengcheng Zhang, Zhengxing Zhang, Jutta Zeisler, Nadine Colpo, Kuo‐Shyan Lin, François Bénard
Abstract
Ga]Ga-CCZ01099 showed clear tumor visualization and excellent tumor-to-normal tissue contrast with PET imaging in a preclinical melanoma model. Therefore, CCZ01099 is a promising compound for imaging and potentially radioligand therapy for melanoma.
Topics & Concepts
Positron emission tomographyRadioligandMelanomaInternalizationMelanocortin 1 receptorCancer researchMelanocyte-stimulating hormoneChemistryPositron Emission Tomography-Computed TomographyMedicineReceptorNuclear medicineInternal medicineOncologyBiochemistryGeneAlleleChemical Synthesis and AnalysisReceptor Mechanisms and SignalingRNA and protein synthesis mechanisms