GSH/pH dual responsive chitosan nanoparticles for reprogramming M2 macrophages and overcoming cancer chemoresistance
Xinzhi Zhao, Chunxiong Zheng, Ying Wang, Jialei Hao, Yang Liu
Abstract
studies have demonstrated the effectiveness of GPNP in reprogramming M2 macrophages and inducing apoptosis in MCF-7/ADR cells, resulting in enhanced antitumor efficacy. This work proposed an effective combination strategy to combat chemoresistance, providing new insights into the development of innovative combinatorial therapies against MDR tumors.
Topics & Concepts
ChitosanReprogrammingChemistryGlutathioneCancer researchMacrophageDual (grammatical number)ChemotherapyCell biologyBiochemistryBiologyCellEnzymeIn vitroArtGeneticsLiteratureImmune cells in cancerEpigenetics and DNA MethylationNanoplatforms for cancer theranostics