Nanodrug regulates lactic acid metabolism to reprogram the immunosuppressive tumor microenvironment for enhanced cancer immunotherapy
Li-Rong Tian, Minzhao Lin, Huihai Zhong, Yujun Cai, Bo Li, Zecong Xiao, Xintao Shuai
Abstract
studies demonstrated that the decreased extracellular lactate preferentially polarized TAMs to the M1 phenotype, simultaneously increased the proportion of NK cells and reduced the number of Treg cells. These results validated an efficient tumor immunotherapy in the breast cancer model. This new strategy of lactic acid metabolism regulation is proposed to operate in concert with immune modulation in the TME, which shows great potential for immunotherapy of immunologically "cold" tumors.
Topics & Concepts
Tumor microenvironmentImmunotherapyImmune systemCancer researchCancer immunotherapyImmunosuppressionCytotoxic T cellGlycolysisBiologyCancer cellCancerChemistryImmunologyMetabolismBiochemistryIn vitroGeneticsImmune cells in cancerEpigenetics and DNA MethylationCancer, Hypoxia, and Metabolism