Early-Onset Type 2 Diabetes as a Risk Factor for End-Stage Renal Disease in Patients With Diabetic Kidney Disease
Zheng Li, Xiangjun Chen, Ting Luo, Xi Ran, Jinbo Hu, Qingfeng Cheng, Shumin Yang, Jinshan Wu, Qifu Li, Zhihong Wang
Abstract
INTRODUCTION: Compared with the typical onset of type 2 diabetes in middle age or older, type 2 diabetes with early age of onset has a higher risk of diabetes-related complications. It is unclear whether the early age of diabetes diagnosis would affect the development of end-stage renal disease (ESRD) in patients with diabetic kidney disease (DKD) who are at higher risk of ESRD. METHODS: or dialysis. Logistic regression analysis was used to explore the association between early-onset diabetes and ESRD. RESULTS: Early-onset diabetes patients had a longer diabetes duration, higher body mass index, and worse blood lipid metabolism profile. Compared with late-onset diabetes patients, patients with early-onset diabetes had a prevalence of ESRD that was twofold higher (9.2% vs 4.3%; P = .009). Univariate analysis showed that early-onset diabetes was a risk factor for ESRD in patients with DKD (P < .05). In multivariate logistic regression analysis, even after adjusting for sex, traditional metabolic factors, drug factors, and diabetes duration, the risk of ESRD in patients with early-onset diabetes was still 3.58-fold higher than in subjects with late-onset (95% CI, 1.47-8.74; P = .005). CONCLUSIONS: In patients with DKD, early-onset type 2 diabetes is an independent risk factor of ESRD.