Practical issues in CAR T-cell therapy
Ja Min Byun
Abstract
Chimeric antigen receptor (CAR) T-cell therapy presents a revolutionary advancement in personalized cancer treatment. During the production process, the patient's own T-cells are genetically engineered to express a synthetic receptor that binds to a tumor antigen. CAR T-cells are then expanded for clinical use and infused back into the patient's body to attack cancer cells. Although CAR T-cell therapy is considered a major breakthrough in cancer immunotherapy, it is not without limitations. In this review, we discuss the barriers to effective CAR T-cell therapy in Korea.
Topics & Concepts
Chimeric antigen receptorMedicineCell therapyImmunotherapyCancer therapyCancer immunotherapyCancerGenetic enhancementAntigenCAR T-cell therapyCancer researchT cellImmunologyCellOncologyInternal medicineImmune systemGeneBiologyGeneticsCAR-T cell therapy researchNanowire Synthesis and ApplicationsViral Infectious Diseases and Gene Expression in Insects