SMURF1 activates the cGAS/STING/IFN-1 signal axis by mediating YY1 ubiquitination to accelerate the progression of lupus nephritis
Xiaoyan Li, Sisi Tao, Zhiquan Xu, Yi Ren, Wei Xiang, Xiaojie He
Abstract
. In short, SMURF1 upregulation activated the cGAS/STING/IFN-1 signal axis by regulating YY1 ubiquitination to facilitate apoptosis in podocytes during LN progression.
Topics & Concepts
Downregulation and upregulationApoptosisGene knockdownCancer researchYY1BiologyLupus nephritisTUNEL assayMolecular biologyCell biologyChemistryMedicineInternal medicineGene expressionPromoterBiochemistryGeneDiseaseinterferon and immune responsesInflammasome and immune disordersSystemic Lupus Erythematosus Research