A novel approach for on-site screening of organophosphorus nerve agents based on DTNB modified AgNPs using surface-enhanced Raman spectrometry
Jianfeng Wu, Ying‐Jie Zhu, Yulong Liu, Jia Chen, Lei Guo, Jianwei Xie
Abstract
. The introduction of DTNB as an enzyme activity indicator significantly improves the detection sensitivity with distinct characteristic Raman peaks. The LOD of GD, which is one of the most easily aged OPNAs, could reach 0.1 nM due to its strongest inhibition of AChE. Moreover, various OPNAs exhibit different SERS intensities due to their different inhibition capacities of AChE. Hence, the new strategy has great potential in public security early warning and environmental analysis.
Topics & Concepts
DTNBNerve agentChemistrySomanAcetylcholinesteraseTabunAcetylthiocholineAchéRaman spectroscopyDetection limitCombinatorial chemistryNanotechnologyChromatographyBiochemistryEnzymeMaterials scienceGlutathionePhysicsOpticsPesticide Exposure and ToxicityInsect and Pesticide ResearchEnvironmental Toxicology and Ecotoxicology