Enantioselective and Regiodivergent Skeletal Transformations of 1,2,3-Thiadiazoles to Alkylidene Dihydrothiophenes
Cunzhi Chen, You-Wei Chen, Hongguang Du, Jiaxi Xu, Zhanhui Yang
Abstract
By leveraging the Rh-catalyzed asymmetric skeletal editing of 1,2,3-thiadiazoles, we successfully achieve the ligand-controlled enantioselective and regiodivergent synthesis of structurally diverse 2- and 3-alkylidene 2,3-dihydrothiophenes. Late-stage structural editing of complex natural and drug molecules is also enabled.
Topics & Concepts
Enantioselective synthesisChemistryThiadiazolesStereochemistryOrganic chemistryCatalysisSulfur-Based Synthesis TechniquesSynthesis and Catalytic ReactionsCyclopropane Reaction Mechanisms