Gastric Metabolomics Detects Helicobacter pylori Correlated Loss of Numerous Metabolites in Both the Corpus and Antrum
Daniela Keilberg, Nina G. Steele, Sili Fan, Christina Yang, Yana Zavros, Karen M. Ottemann
Abstract
Helicobacter pylori is a chronic bacterial pathogen that thrives in several regions of the stomach, causing inflammation that can vary by site and result in distinct disease outcomes. Whether the regions differ in terms of host-derived metabolites is not known. We thus characterized the regional variation of the metabolomes of mouse gastric corpus and antrum organoids and tissue. The uninfected secreted organoid metabolites differed between the corpus and antrum in only seven metabolites as follows: lactic acid, malic acid, phosphoethanolamine, alanine, uridine, glycerol, and isoleucine.
Topics & Concepts
BiologyAntrumHelicobacter pyloriMetabolomicsGlutamineMetabolomeMetaboliteOrganoidStomachMicrobiologyBiochemistryAmino acidBioinformaticsGeneticsHelicobacter pylori-related gastroenterology studiesMicrobial Metabolites in Food BiotechnologyPhytochemistry and Bioactive Compounds