Melatonin rescues cell respiration impaired by hypoxia/reoxygenation in aortic endothelial cells and affects the mitochondrial bioenergetics targeting the F1FO-ATPase
Cristina Algieri, Chiara Bernardini, Antonia Cugliari, Silvia Granata, Fabiana Trombetti, Patrycja Anna Glogowski, Micaela Fabbri, Giampaolo Morciano, Gaia Pedriali, Paolo Pinton, Salvatore Nesci
Abstract
. Moreover, the impairment of bioenergetics parameters in pAECs metabolism and the increase of oxidative stress arising by H/R injury have been rescued in cells protected by melatonin treatment.
Topics & Concepts
BioenergeticsHypoxia (environmental)MitochondrionCell biologyRespirationBiologyMelatoninOxidative phosphorylationOxygenInternal medicineChemistryEndocrinologyAnatomyMedicineBiochemistryOrganic chemistryBirth, Development, and HealthATP Synthase and ATPases ResearchHormonal Regulation and Hypertension