Myristoleic Acid Promotes Anagen Signaling by Autophagy through Activating Wnt/β-Catenin and ERK Pathways in Dermal Papilla Cells
Youn Kyung Choi, Jung-Il Kang, Jin Won Hyun, Young Sang Koh, Ji‐Hoon Kang, Chang‐Gu Hyun, Kyung‐Sup Yoon, Kwang‐Sik Lee, Chun Mong Lee, Tae Yang Kim, Eun-Sook Yoo, Hee‐Kyoung Kang
Abstract
)-extracellular signal regulated kinases (ERK). MA-induced ERK phosphorylation led to changes in the expression levels of Cdc2, Atg7 and LC3II, as well as DPC proliferation. Our results suggest that MA promotes anagen signaling via autophagy and cell cycle progression by activating the Wnt/β-catenin and ERK pathways in DPCs.
Topics & Concepts
Wnt signaling pathwayAutophagyMAPK/ERK pathwayCell biologyCateninDermal papillaeBiologySignal transductionChemistryBiochemistryApoptosisHair follicleHair Growth and Disordersmelanin and skin pigmentationDermatologic Treatments and Research