Deletion of the inhibitory co-receptor CTLA-4 enhances and invigorates chimeric antigen receptor T cells
Sangya Agarwal, M. Ángela Aznar, Andrew J. Rech, Charly R. Good, Shunichiro Kuramitsu, Tong Da, Mercy Gohil, Linhui Chen, Seok-Jae Albert Hong, Pranali Ravikumar, Austin K. Rennels, January Salas-McKee, Weimin Kong, Marco Ruella, Megan M. Davis, Gabriela Plesa, Joseph A. Fraietta, David L. Porter, Regina M. Young, Carl H. June
Topics & Concepts
Chimeric antigen receptorBiologyCD28T cellAntigenCancer researchChronic lymphocytic leukemiaImmunologyLeukemiaCD19Immune systemCAR-T cell therapy researchImmune Cell Function and InteractionT-cell and B-cell Immunology