Targeted brachyury degradation disrupts a highly specific autoregulatory program controlling chordoma cell identity
Hadley E. Sheppard, Alessandra Dall’Agnese, Woojun D. Park, Md Shamim, Julien Dubrulle, Hannah L. Johnson, Fabio Stossi, Patricia C. Cogswell, Josh Sommer, Joan Levy, Tanaz Sharifnia, Mathias J. Wawer, Behnam Nabet, Nathanael S. Gray, Paul A. Clemons, Stuart L. Schreiber, Paul Workman, Richard A. Young, Charles Y. Lin
Abstract
to anti-apoptotic inhibition. These data suggest that brachyury downregulation is a core tenet of transcriptional CDK inhibition and motivates developing strategies to target brachyury and its autoregulatory feedback loop.
Topics & Concepts
BrachyuryIdentity (music)Degradation (telecommunications)Cell biologyChemistryBiologyComputer scienceBiochemistryArtTelecommunicationsEmbryonic stem cellAestheticsGeneMesodermProtein Degradation and Inhibitorsinterferon and immune responsesUbiquitin and proteasome pathways