Human Carbonic Anhydrase Inhibitors
Claudiu T. Supuran
Abstract
Humans encode 15 isoforms of the metalloenzyme carbonic anhydrase (CA, EC 4.2.1.1), which catalyzes the interconversion between CO 2 and bicarbonate and is involved in a multitude of physiological/pathological processes. CA inhibitors are in clinical use as diuretics, anti-glaucoma drugs, anti-epileptics, and anti-obesity agents. Novel applications as anti-tumor/anti-metastatic agents, or for the management of cerebral ischemia, rheumatoid arthritis, and neurodegenerative conditions, are discussed for the more than 45 chemotypes with inhibitory properties against these enzymes.
Topics & Concepts
Carbonic anhydraseCarbonic anhydrase IIMedicineComputer scienceData sciencePharmacologyChemistryBiochemistryEnzymeEnzyme function and inhibitionSynthesis and Catalytic ReactionsChemical Reactions and Mechanisms