Switching a conflicted bacterial DTD-tRNA code is essential for the emergence of mitochondria
Jotin Gogoi, Akshay Bhatnagar, Kezia J Ann, Sambhavi Pottabathini, Raghvendra Singh, Mohd Mazeed, Santosh Kumar Kuncha, Shobha P. Kruparani, Rajan Sankaranarayanan
Abstract
discriminator element is the only one to switch from pyrimidine to purine during the bacteria-to-mitochondria transition. We capture this code transition in the Jakobida, an early diverging eukaryotic clade bearing the most bacterial-like mito-genome, wherein both discriminator elements are present. This study underscores the need to explore the fundamental integration strategies critical for mitochondrial and eukaryotic evolution.
Topics & Concepts
Transfer RNAComputer scienceMitochondrionCode (set theory)Computational biologyGenetic codeProgramming languageBiologyNatural language processingGeneticsRNADNASet (abstract data type)GeneRNA and protein synthesis mechanismsGenomics and Phylogenetic StudiesMitochondrial Function and Pathology