Dynamic kinetic resolution of γ,γ-disubstituted indole 2-carboxaldehydes<i>via</i>NHC-Lewis acid cooperative catalysis for the synthesis of tetracyclic ε-lactones
Kuruva Balanna, Soumen Barik, Sayan Shee, Rajesh G. Gonnade, Akkattu T. Biju
Abstract
NHC-Lewis acid cooperative catalyzed dynamic kinetic resolution (DKR) of transiently generated γ,γ-disubstituted indole 2-carboxaldehydes leading to the enantioselective synthesis of tetracyclic ε-lactones is reported.
Topics & Concepts
Kinetic resolutionIndole testChemistryEnantioselective synthesisLewis acids and basesCatalysisCarbeneAnnulationYield (engineering)Combinatorial chemistryOrganic chemistryStereochemistryMetallurgyMaterials scienceSynthesis of Indole DerivativesN-Heterocyclic Carbenes in Organic and Inorganic ChemistryCatalytic Cross-Coupling Reactions