Carbon Monoxide in Organic Synthesis

Abstract

In this chapter, processes of great industrial interest such as rhodium-catalyzed hydroformylation
\nand carbonylation are discussed. Much has been written on these reactions, and it would not have
\nbeen possible, for editorial reasons, to give an overview of the results obtained since the origins of
\nthese processes up to now. Therefore, we have decided to limit our field of action to the data
\nappeared in the literature starting from 2015 until today. However, the plethora of published papers
\nforced us to pick, certainly arbitrary, those articles that we consider most significant. In particular,
\nwe focused on some particular aspects of these processes, namely, the recovery and recycling of
\nthe homogeneous catalyst, as it represents a thorn in the side of these industrial homogenous
\nprocesses, on the aqueous biphasic catalysis, an elegant way to perform a more sustainable
\nreaction;, on the enantioselective hydroformylation to obtain valuable intermediates for fine
\nchemicals on tandem reaction that allows to produce functionalized compounds; and, lastly, on the
\nuse of substitutes of the hazardous CO with safer substances.

Topics & Concepts