Optimized human intestinal organoid model reveals interleukin-22-dependency of paneth cell formation
Gui‐Wei He, Lin Lin, Jeff DeMartino, Xuan Zheng, Nadzeya Staliarova, Talya L. Dayton, Harry Begthel, Willine J. van de Wetering, Eduard Bodewes, Jeroen S. van Zon, Sander J. Tans, Carmen Lopez-Iglesias, Peter J. Peters, Wei Wu, Daniel Kotlarz, Christoph Klein, Thanasis Margaritis, Frank C. P. Holstege, Hans Clevers
Abstract
(Cell Stem Cell 29, 1333–1345.e1–e6; September 1, 2022) In Figure 1B of the originally published version of this manuscript, the authors mistakenly indicated that IL-22 was not included in the culturing medium for optimal patterning. However, IL-22 was in fact included, as indicated correctly in the diagram in Figure 1A. The authors have now replaced the incorrect minus sign in the IL-22 row at the bottom of Figure 1B with a correct plus sign in both the article online and the image included below, and they apologize for the confusion.Figure 1Optimal culture of human intestinal organoids with multi-differentiation capacity (original)View Large Image Figure ViewerDownload Hi-res image Download (PPT) Optimized human intestinal organoid model reveals interleukin-22-dependency of paneth cell formationHe et al.Cell Stem CellAugust 23, 2022In BriefGenerating a long-term organoid culture model that displays extensive budding and harbors all cell types of the human small intestine reveals mechanism of human Paneth cell differentiation by IL-22-mTOR signaling. Full-Text PDF Open Access