Nine days extended release of adenosine from biocompatible MOFs under biologically relevant conditions
Worood A. El‐Mehalmey, Najma Latif, Ahmed H. Ibrahim, Rana R. Haikal, Paulina Mierzejewska, Ryszard T. Smoleński, Magdi H. Yacoub, Mohamed H. Alkordi
Abstract
The stability of Zr–MOFs and the widely used Zn-based (ZIF-8) was investigated in physiologically relevant media, where detailed mechanistic investigations clearly demonstrated that the observed cytotoxicity of ZIF-8 is linked to its structural instability in simulant fluids, in contrast to the highly stable Zr-MOFs.
Topics & Concepts
CytotoxicityBiocompatible materialBiocompatibilityChemistryAdenosineHeLaBiophysicsViability assayCellCell cultureBiochemistryIn vitroBiomedical engineeringBiologyMedicineOrganic chemistryGeneticsMetal-Organic Frameworks: Synthesis and ApplicationsCovalent Organic Framework ApplicationsCorrosion Behavior and Inhibition