Low-dose exposure to phytosynthesized gold nanoparticles combined with glutamine deprivation enhances cell death in the cancer cell line HeLa <i>via</i> oxidative stress-mediated mitochondrial dysfunction and G0/G1 cell cycle arrest
Abhinav Prasad, Ashapurna Khatua, Yugal Kishore Mohanta, Muthupandian Saravanan, Ramovatar Meena, Ilora Ghosh
Abstract
apoptosis/necrosis, and inhibition of migration capacities of HeLa cells were also seen after the combined treatment. Thus, this research provides insight into a new combinatorial approach for reducing the dose of nanoparticles and increasing their efficacy to better inhibit the growth of human cervical cancer cells by leveraging their extracellular glutamine dependence.
Topics & Concepts
HeLaOxidative stressGlutamineMitochondrionCell cultureProgrammed cell deathCellColloidal goldChemistryCancer researchApoptosisCell biologyNanoparticleBiochemistryMedicineBiologyMaterials scienceNanotechnologyGeneticsAmino acidVitamin C and Antioxidants ResearchCancer, Hypoxia, and MetabolismCancer Research and Treatments