Gallium-Labeled PET Radiopharmaceuticals in Cardiovascular Disease
Matthieu Bailly, A.C. Dupont, Guillaume Domain, Diane Darsin-Bettinger, Maxime Courtehoux, Gilles Metrard, Alain Manrique, Jonathan Vigne
Abstract
Gallium-labeled positron emission tomography (PET) probes targeting activated fibroblasts or somatostatin receptor expression are frequently used for varying applications in oncology. With the widespread availability of 68Ge/68Ga generators and cold kits, 68Ga tracers have become a main tool in molecular imaging. These tracers, such as [68Ga]Ga-DOTA-TATE, [68Ga]Ga-FAPI, and [68Ga]Ga-pentixafor, allow targeted imaging of the key pathological processes, including inflammation, fibrosis, and necrosis. This review highlights their potential in conditions like myocardial infarction, cardiac sarcoidosis, myocarditis, and other cardiomyopathies. Clinical and preclinical studies underscore their utility in visualizing active disease processes, predicting outcomes, and guiding therapeutic strategies. However, challenges remain, including the need for standardization, larger clinical trials, and integration into routine practice. These advancements position 68Ga-based PET as a promising modality for enhancing diagnostic precision and personalized treatment in cardiovascular disease.