A two-metalloenzyme cascade constructs the azetidine-containing pharmacophore
Rong Gong, Yao Qu, Jia Liu, Xuan Zhang, Liwei Zhou, Tian Zhu, Xinyue Zeng, Bo Jin, Zhen Li, Le Yu, Ruyi Chen, Yang Zhou, Langxing Liao, Liulin Yang, Xuemin Song, You‐Sheng Cai, Kun Shen, Zixin Deng, Zhengyu Zhang, Binju Wang, Wenqing Chen
Topics & Concepts
ChemistryPharmacophoreMoietyIntramolecular forceStereochemistryCascadeCombinatorial chemistryRational designEnzymeMechanism (biology)Dual (grammatical number)Dual roleDrug discoveryMoleculeSmall moleculeStereoisomerismAzetidinePhthalimideCascade reactionMolecular conformationSynthesis and Catalytic ReactionsCyclopropane Reaction MechanismsChemical Synthesis and Analysis