Assessment of Hepatocellular Carcinoma Response to <sup>90</sup>Y Radioembolization Using Dynamic Contrast Material–enhanced MRI and Intravoxel Incoherent Motion Diffusion-weighted Imaging
Stefanie J. Hectors, Sara Lewis, Paul Kennedy, Octavia Bane, Daniela Said, Maxwell Segall, Myron Schwartz, Edward Kim, Bachir Taouli
Abstract
Purpose: Y) radioembolization and to assess the value of dynamic contrast material-enhanced (DCE) MRI and intravoxel incoherent motion (IVIM) diffusion-weighted imaging (DWI) for predicting HCC response. Materials and Methods: = 21) after radioembolization. IVIM DWI and DCE MRI histogram parameters were quantified in HCCs and liver parenchyma. HCC response was assessed by using modified Response Evaluation Criteria in Solid Tumors at 6 weeks and 6-12 months after radioembolization. Logistic regression analysis was used to evaluate the diagnostic performance of baseline MRI and clinical parameters for prediction of response. Results: kurtosis (AUC = 0.916) for prediction of objective and complete response at 6 weeks, respectively. Standard deviation of DCE MRI parameter arterial fraction was selected as the optimal predictor for complete response at 6-12 months (AUC = 0.857). Conclusion: © RSNA, 2020.