Identification of Antibiotics That Diminish Disease in a Murine Model of Enterohemorrhagic Escherichia coli Infection
Sabrina Mühlen, Isabell Ramming, Marina C. Pils, Martin B. Koeppel, Jana Glaser, John M. Leong, Antje Flieger, Bärbel Stecher, Petra Dersch
Abstract
Infections with enterohemorrhagic Escherichia coli (EHEC) cause disease ranging from mild diarrhea to hemolytic-uremic syndrome (HUS) and are the most common cause of renal failure in children in high-income countries. The severity of the disease derives from the release of Shiga toxins (Stx). The use of antibiotics to treat EHEC infections is generally avoided, as it can result in increased stx expression. Here, we systematically tested different classes of antibiotics and found that their influence on stx expression and release varies significantly.
Topics & Concepts
Escherichia coliAntibioticsMicrobiologyShiga toxinDiarrheaBiologyDiseaseVirologyMedicineInternal medicineGeneBiochemistryEscherichia coli research studiesViral gastroenteritis research and epidemiologyGut microbiota and health