Discovery of a heme-binding domain in a neuronal voltage-gated potassium channel
Mark J. Burton, Joel Cresser-Brown, Morgan Thomas, Nicola Portolano, Jaswir Basran, Samuel L. Freeman, Hanna Kwon, Andrew R. Bottrill, Manuel J. Llansola‐Portoles, Andrew A. Pascal, Rebekah Jukes‐Jones, Tatyana Chernova, Ralf Schmid, Noel W. Davies, Nina M. Storey, Pierre Dorlet, P.C.E. Moody, John S. Mitcheson, Emma Lloyd Raven
Abstract
and, using spectroscopy and kinetics, identified the PAS domain as the location for heme binding. The results identify heme as a regulator of hERG3 channel activity. These observations are discussed in the context of the emerging role for heme as a regulator of ion channel activity in cells.
Topics & Concepts
Potassium channelHemeChemistryBiophysicsNeuroscienceCell biologyBiochemistryBiologyEnzymeIon channel regulation and functionNeuroscience and Neuropharmacology ResearchCardiac electrophysiology and arrhythmias