Direct synthesis of haloaromatics from nitroarenes <i>via</i> a sequential one-pot Mo-catalyzed reduction/Sandmeyer reaction
Raquel Hernández‐Ruiz, Sara Gómez‐Gil, M.R. Pedrosa, Samuel Suárez‐Pantiga, Roberto Sanz
Abstract
Herein, we report the direct synthesis of a wide variety of functionalized aromatic bromides, chlorides, iodides, and fluorides from nitroarenes in a sequential one-pot operation. This protocol is based on an air- and moisture-tolerant dioxomolybdenum-catalyzed reduction of nitroaromatics, employing pinacol as a reducing agent, which enables subsequent diazotization and halogenation steps. This methodology represents a step-economical, practical, and alternative procedure for synthesizing haloaromatics directly from nitroaromatics.
Topics & Concepts
ChemistryCatalysisReduction (mathematics)Combinatorial chemistryMedicinal chemistryOrganic chemistryGeometryMathematicsNanomaterials for catalytic reactionsCatalytic C–H Functionalization MethodsCatalytic Cross-Coupling Reactions