Design, synthesis, molecular modeling, and biological evaluation of pyrazole-naphthalene derivatives as potential anticancer agents on MCF-7 breast cancer cells by inhibiting tubulin polymerization
Guangcheng Wang, Wenjing Liu, Zhiyun Peng, Yong Huang, Zipeng Gong, Yongjun Li
Topics & Concepts
ChemistryTubulinMCF-7StereochemistryColchicinePyrazoleCisplatinCell cycleDocking (animal)Lead compoundCell cycle checkpointIC50Cancer cellIn vitroApoptosisMicrotubuleCancerBiochemistryHuman breastSurgeryCell biologyChemotherapyNursingMedicineBiologyInternal medicineSynthesis and biological activitySynthesis and Characterization of Heterocyclic CompoundsSynthesis and Biological Evaluation