Activation of autophagy and suppression of apoptosis by dapagliflozin attenuates experimental inflammatory bowel disease in rats: Targeting AMPK/mTOR, HMGB1/RAGE and Nrf2/HO-1 pathways
Hany H. Arab, Muhammad Y. Al‐Shorbagy, Muhammed A. Saad
Topics & Concepts
DapagliflozinAutophagyPI3K/AKT/mTOR pathwayAMPKHMGB1Inflammatory bowel diseaseOxidative stressInflammationApoptosisPharmacologyMedicineProinflammatory cytokineMetforminChemistryEndocrinologyCancer researchInternal medicineDiabetes mellitusProtein kinase ABiochemistryType 2 diabetesKinaseDiseaseAdenosine and Purinergic SignalingAutophagy in Disease and TherapyGenomics, phytochemicals, and oxidative stress