Synthesis, in silico, in vitro and in vivo evaluations of isatin aroylhydrazones as highly potent anticonvulsant agents
Saeed Emami, Mehdi Valipour, Fatemeh Kazemi Komishani, Fatemehsadat Sadati-Ashrafi, Maria Rasoulian, Majid Ghasemian, Mahmood Tajbakhsh, Patrick Honarchian Masihi, Aidin Shakiba, Hamid Irannejad, Nematollah Ahangar
Topics & Concepts
IsatinChemistryAnticonvulsantIn vivoADMELipophilicityIn silicoPharmacologyIn vitroDocking (animal)Lipinski's rule of fiveStereochemistryProton NMRCytotoxicityGABAA receptorCombinatorial chemistryReceptorBiochemistryEpilepsyOrganic chemistryMedicineGeneNeuroscienceBiologyNursingBiotechnologyComputational Drug Discovery MethodsSynthesis and biological activityPhenothiazines and Benzothiazines Synthesis and Activities