Polyketides with Anti-Inflammatory Activity from <i>Trichoderma koningiopsis</i>, a Rhizosphere Fungus from the Medicinal Plant <i>Polygonum paleaceum</i>
Liping Huang, Mengsha Wei, Lanqin Li, Qin Li, Weiguang Sun, Xiaotan Yu, Feng‐Qing Wang, Zhengxi Hu, Chunmei Chen, Hucheng Zhu, Yonghui Zhang
Abstract
Twelve new fungal polyketides, koningiopisins I–P ( 1 – 8 ) and trichoketides C–F ( 9 – 12 ), together with six known congeners ( 13 – 18 ), were isolated from Trichoderma koningiopsis, a rhizosphere fungus obtained from the medicinal plant Polygonum paleaceum . Their structures and absolute configurations were established by spectroscopic analysis, single-crystal X-ray diffraction, the modified Mosher’s method, chemical derivatization, the octant rule, and 13 C NMR and ECD calculations. Compounds 1 – 5 are tricyclic polyketides possessing an octahydrochromene framework with a 6,8-dioxabicyclo[3.2.1]octane core. Compounds 7 and 8 contain a unique ketone carbonyl group at C-7 and differ from other members of this group of compounds with the ketone carbonyl group at C-1. Compounds 1, 2, and 13 showed inhibitory activity on LPS-induced BV-2 cells on NO production with IC 50 values of 14 ± 1, 3.0 ± 0.5, and 8.9 ± 2.7 μM, respectively.