Stimulating the autophagic-lysosomal axis enhances host defense against fungal infection in a zebrafish model of invasive Aspergillosis
Gabriel Forn‐Cuní, L Welvaarts, FM Stel, Cees A. M. J. J. van den Hondel, Mark Arentshorst, Arthur F. J. Ram, Annemarie H. Meijer
Abstract
DMSO: dimethyl sulfoxide; HR: hazard ratio; HDT: host-directed therapy; Hpf: hours post fertilization; IA: invasive Aspergillosis; LAP: LC3-associated phagocytosis; MTZ: metronidazole; PTU: N-phenylthiourea; ROS: reactive oxygen species.
Topics & Concepts
Aspergillus fumigatusBiologyAutophagyPhagocytosisZebrafishMicrobiologyAspergillosisATG5ImmunologyApoptosisGeneBiochemistryAutophagy in Disease and TherapyNeutrophil, Myeloperoxidase and Oxidative MechanismsCalcium signaling and nucleotide metabolism