Unfolded protein response at the cross roads of tumourigenesis, oxygen sensing and drug resistance in clear cell renal cell carcinoma
Yew Hwang Chee, Afshin Samali, Claire M. Robinson
Abstract
Clear cell renal cell carcinoma (ccRCC) is the most common form of kidney cancer. Despite therapeutic advances, long term survival in patients diagnosed with advanced disease is low. Efforts to understand the mechanisms promoting disease progression will likely produce novel therapeutic targets. The unfolded protein response (UPR) is activated when unfolded protein accumulates in the endoplasmic reticulum (ER) upon cellular stress. Constitutive UPR activation is a characteristic of many malignancies. We discuss the accumulating evidence that describes a role for the UPR in ccRCC. Studies focused on UPR signalling may provide compelling avenues for therapeutic intervention in the future.
Topics & Concepts
Unfolded protein responseEndoplasmic reticulumCancer researchCellClear cell renal cell carcinomaMedicineRenal cell carcinomaDrug resistanceDiseaseBiologyCell biologyOncologyInternal medicineGeneticsMicrobiologyEndoplasmic Reticulum Stress and DiseaseGenetic and Kidney Cyst DiseasesRenal cell carcinoma treatment