Mitochondrial spare respiratory capacity: Mechanisms, regulation, and significance in non‐transformed and cancer cells
Philippe Marchetti, Quentin Fovez, Nicolas Germain, Raeeka Khamari, Jérôme Kluza
Abstract
Mitochondrial metabolism must constantly adapt to stress conditions in order to maintain bioenergetic levels related to cellular functions. This absence of proper adaptation can be seen in a wide array of conditions, including cancer. Metabolic adaptation calls on mitochondrial function and draws on the mitochondrial reserve to meet increasing needs. Among mitochondrial respiratory parameters, the spare respiratory capacity (SRC) represents a particularly robust functional parameter to evaluate mitochondrial reserve. We provide an overview of potential SRC mechanisms and regulation with a focus on its particular significance in cancer cells.
Topics & Concepts
BioenergeticsMitochondrionSpare partAdaptation (eye)Cell biologyBiologyFunction (biology)Mitochondrial respiratory chainNeuroscienceBusinessMarketingMitochondrial Function and PathologyAdipose Tissue and MetabolismCancer, Hypoxia, and Metabolism