A literature perspective on the pharmacological applications of yohimbine
Nasimudeen R. Jabir, Chelapram K. Firoz, Torki A. Zughaibi, Mohammed Alsaadi, Adel Abuzenadah, Ahmed I. Al‐Asmari, Ahdab Alsaieedi, Abdul Bakrudeen Ali Ahmed, Arun Kumar Ramu, Shams Tabrez
Abstract
The current review highlights some significant findings that contribute to developing yohimbine-based drugs. It also highlights the therapeutic potential of yohimbine against selected human diseases. However, further research is recommended on the pharmacokinetics, molecular mechanisms, and drug safety requirements using well-designed randomized clinical trials to produce yohimbine as a pharmaceutical agent for human use.Key MessagesYohimbine is a natural indole alkaloid with significant pharmacological potential.Humans have used it as a stimulant and aphrodisiac from a relatively early time.It blocks the pre- and postsynaptic α2-adrenergic receptors that could be exploited for managing erectile dysfunction, myocardial dysfunction, inflammatory disorders, and cancer.