Ethanol-assisted mechanochemical asymmetric cross-dehydrogenative coupling reaction with recoverable chiral amine/NaCl for accessing chiral α-alkyl α-glycine derivatives
Jingbo Yu, Hongsong Chen, Ziwen Zhang, Yuxin Fang, Tao Ying, Weike Su
Abstract
Ethanol-assisted grinding effectively facilitated aerobic asymmetric cross-dehydrogenative coupling of glycine esters/amides with ketones/aldehydes, deploying reusable chiral amine/NaCl for rapid synthesis of chiral α-alkyl α-glycine derivatives.
Topics & Concepts
AlkylGlycineChemistryAmine gas treatingEthanolCoupling (piping)Coupling reactionMedicinal chemistryOrganic chemistryCombinatorial chemistryCatalysisMaterials scienceAmino acidBiochemistryMetallurgyAxial and Atropisomeric Chirality SynthesisAdvanced Synthetic Organic ChemistryAlkaloids: synthesis and pharmacology