Follistatin-like 1 promotes proliferation of matured human hypoxic iPSC-cardiomyocytes and is secreted by cardiac fibroblasts
Marijn M.C. Peters, Sofia Di Martino, Thomas Boelens, Jiabin Qin, Alain van Mil, Pieter A. Doevendans, Steven A. J. Chamuleau, Joost P. G. Sluijter, Klaus Neef
Abstract
hypoxia damage model. Furthermore, we show hypoxia-related FSTL1 secretion by human cFBs and indications for FSTL1-mediated intercellular communication between cardiac cell types in response to hypoxic conditions.
Topics & Concepts
FollistatinHypoxia (environmental)Induced pluripotent stem cellSecretionCell biologyApoptosisBiologyIn vitroMesenchymal stem cellCardiac cellInternal medicineEmbryonic stem cellMedicineChemistryEndocrinologyBiochemistryGeneOrganic chemistryOxygenCongenital heart defects researchCardiac Fibrosis and RemodelingRNA Research and Splicing