Four keys to unlock IgG
Falk Nimmerjahn, Jeffrey V. Ravetch
Abstract
The identification of discrete subclasses within the immunoglobulin G (IgG) isotype by Grey and Kunkel (1964. J. Exp. Med.https://doi.org/10.1084/jem.120.2.253) provided the framework for our current understanding of differential IgG subclass activity in protective and self-reactive immune responses.
Topics & Concepts
SubclassIsotypeImmunoglobulin GAntibodyImmunologyImmune systemIdentification (biology)BiologyComputational biologyMonoclonal antibodyBotanyMonoclonal and Polyclonal Antibodies ResearchImmune Cell Function and InteractionT-cell and B-cell Immunology