Direct observation of protein structural transitions through entire amyloid aggregation processes in water using 2D-IR spectroscopy
So Yeon Chun, Myung Kook Son, Chae Ri Park, Chaiho Lim, Hugh I. Kim, Kyungwon Kwak, Minhaeng Cho
Abstract
This study aims to understand the structural transition dynamics of INS during amyloid aggregation in H 2 O using 2D-IR spectroscopy. The results show that distinct fibrillations in D 2 O and H 2 O originated from different quaternary structures of INS.
Topics & Concepts
ChemistryMolecular dynamicsSpectroscopyInfrared spectroscopyChemical physicsAmyloid (mycology)DimerProtein aggregationKinetic isotope effectBiophysicsCrystallographyComputational chemistryBiochemistryOrganic chemistryBiologyDeuteriumQuantum mechanicsInorganic chemistryPhysicsSpectroscopy Techniques in Biomedical and Chemical ResearchProtein Structure and DynamicsSpectroscopy and Quantum Chemical Studies