Visible-light-driven selective difluoroalkylation of α-CF<sub>3</sub> alkenes to access CF<sub>2</sub>-containing <i>gem</i>-difluoroalkenes and trifluoromethylalkanes
Panpan Lei, Bingran Chen, Tonghui Zhang, Qinlin Chen, Liangming Xuan, Haifeng Wang, Qiongjiao Yan, Wei Wang, Jie Zeng, Fen‐Er Chen
Abstract
A visible-light-mediated selective difluoroalkylation of α-trifluoromethyl alkenes with difluoroalkylating reagents was developed. This protocol allowed the formation of gem -difluoroalkene difluoroacetates and trifluoromethylated difluoroacetamides.
Topics & Concepts
ChemistryReagentTrifluoromethylVisible spectrumCombinatorial chemistryPhotochemistryOrganic chemistryOptoelectronicsAlkylPhysicsFluorine in Organic ChemistryInorganic Fluorides and Related Compounds