Safety of fluoroquinolones
J Barberán, Alicia de la Cuerda, María Isabel Tejeda González, Ana Aparicio, Carlos Monfort-Vinuesa, Alejandro Ramos Sánchez, Lourdes Cristina Barberán
Abstract
Fluoroquinolones (FQs) are one of the most commonly prescribed classes of antibiotics. Although they were initially well tolerated in randomized clinical trials, subsequent epidemiological studies have reported an increased risk of threatening, severe, long-lasting, disabling and irreversible adverse effects (AEs), related to neurotoxicity and collagen degradation, such as tendonitis, Achilles tendon rupture, aortic aneurysm, and retinal detachment. This article reviews the main potentially threatening AEs, the alarms issued by regulatory agencies and therapeutic alternatives.
Topics & Concepts
MedicineAdverse effectTendonitisNeurotoxicityRandomized controlled trialIntensive care medicineClinical trialSafety profileSurgeryInternal medicineTendonToxicityAntibiotics Pharmacokinetics and EfficacyAnesthesia and Pain ManagementPoisoning and overdose treatments