Differences in gut microbiota structure in patients with stages 4-5 chronic kidney disease.
Rong Wu, Xinglin Ruan, Dan‐dan Ruan, Jianhui Zhang, Hanlu Wang, Quan-Zuan Zeng, Tao Lu, Yu‐Mian Gan, Jie-wei Luo, Jiabin Wu
Abstract
<0.05). The differential bacterial genera with the greatest contribution were, in descending order: c_Bacteroidia, o_Bacteroidales, p_Bacteroidetes, c_Clostridia, o_Clostridiales, etc. Those with the greatest contribution in stages 4-5 CKD were, in descending order: p_Proteobacteria, f_Enterobacteriaceae, o_Enterobacteriales, c_Gammaproteobacteria, c_Bacilli, etc. The results suggest that the diversity of the microbiota may affect the occurrence, development, and outcome of the terminal stages of CKD.
Topics & Concepts
BiologyGammaproteobacteriaClostridiaBacteroidetesGut floraClostridialesKidney diseaseProteobacteriaZoologyPhylumBetaproteobacteriaFirmicutesMicrobiologyPrevotellaImmunologyClostridiaceaeActinobacteriaBacteria16S ribosomal RNAEndocrinologyGeneticsToxinGut microbiota and healthDiet and metabolism studiesGastrointestinal motility and disorders