A murine model of pediatric inflammatory bowel disease causes microbiota-gut-brain axis deficits in adulthood
Eloisa Salvo, Patricia Stokes, Ciara E. Keogh, Ingrid Brust‐Mascher, Carly Hennessey, Trina A. Knotts, Jessica Sladek, Kavi M. Rude, Michelle Swedek, Gonzalo Rabasa, Mélanie G. Gareau
2020American Journal of Physiology-Gastrointestinal and Liver Physiology52 citationsDOIOpen Access PDF
Abstract
Here we describe long-lasting impacts on the microbiota-gut-brain (MGB) axis following administration of low-dose dextran sodium sulfate (DSS) to weaning mice (P21), including gut dysbiosis, colonic inflammation, and brain/behavioral deficits in adulthood (P56). Early-life DSS leads to acute colonic inflammation, similar to adult mice; however, it results in long-lasting deficits in the MGB axis in adulthood (P56), in contrast to the transient deficits seen in adult DSS. This model highlights the unique features of pediatric inflammatory bowel disease.
Topics & Concepts
Gut–brain axisWeaningInflammatory bowel diseaseDysbiosisGut floraInflammationMedicineColitisDiseaseImmunologyPathologyInternal medicineGut microbiota and healthGastrointestinal motility and disordersClostridium difficile and Clostridium perfringens research