Blockade of deubiquitinating enzyme PSMD14 overcomes chemoresistance in head and neck squamous cell carcinoma by antagonizing E2F1/Akt/SOX2-mediated stemness
Chao Jing, Yuansheng Duan, Mengqian Zhou, Kai Yue, Shanshan Zhuo, Xingchen Li, Dandan Liu, Beibei Ye, Qingchuan Lai, Linqi Li, Xiaofeng Yao, Hui Wei, Wenchao Zhang, Yansheng Wu, Xudong Wang
Abstract
Our findings demonstrate the role and mechanism of PSMD14 in HNSCC, and provide a novel and promising target for diagnosis and clinical therapy of HNSCC.
Topics & Concepts
Head and neck squamous-cell carcinomaDeubiquitinating enzymeCancer researchCarcinogenesisIn vivoChromatin immunoprecipitationSOX2Protein kinase BDownregulation and upregulationUbiquitinBiologyCancerTranscription factorChemistryHead and neck cancerSignal transductionCell biologyGene expressionGeneticsPromoterBiochemistryGeneBiotechnologyUbiquitin and proteasome pathwaysCancer-related Molecular PathwaysHistone Deacetylase Inhibitors Research