Discovery, SAR study and ADME properties of methyl 4-amino-3-cyano-1-(2-benzyloxyphenyl)-1<i>H</i>-pyrazole-5-carboxylate as an HIV-1 replication inhibitor
Jeanne Fichez, Cathia Soulié, Laurent Le Corre, Sophie Sayon, Stéphane Priet, Karine Alvarez, Olivier Delelis, Patrick Gizzi, Guillaume Prestat, Christine Gravier‐Pelletier, Anne‐Geneviève Marcelin, Vincent Cálvez, Patricia Busca
Abstract
-pyrazole-5-carboxylate with an advantageous pharmacokinetic profile. Finally, examination of its mode of action revealed that this compound does not belong to the three main classes of anti-HIV drugs, a feature of prime interest in the context of viral resistance.
Topics & Concepts
PyrazoleADMEContext (archaeology)Human immunodeficiency virus (HIV)VirologyPrime (order theory)ChemistryStereochemistryBiologyComputational biologyGeneticsMathematicsCombinatoricsIn vitroPaleontologyHIV/AIDS drug development and treatmentHIV Research and TreatmentPneumocystis jirovecii pneumonia detection and treatment