Electrooxidative tricyclic 6–7–6 fused-system domino assembly to allocolchicines by a removable radical strategy
Yan Zhang, Chanchan Ma, Zhenzhi Cai, Julia Struwe, Shengjie Chen, Jinming Xu, Shiyin Li, Wangyu Zeng, Lutz Ackermann
Abstract
/radical cyclization domino reaction. This approach provides a step-economical and strategically novel disconnection for the facile assembly of a wide range of carbocyclic 6-7-6 fused ring systems. Remarkably, the sulfonyl group on the products could be easily removed by photocatalysis at room temperature with high yields.
Topics & Concepts
ChemistryDominoTricyclicCombinatorial chemistryOrganic chemistryCatalysisRadical Photochemical ReactionsOxidative Organic Chemistry ReactionsCatalytic C–H Functionalization Methods