GPX4 knockdown suppresses M2 macrophage polarization in gastric cancer by modulating kynurenine metabolism
Jingli Xu, Chunyan Weng, Yanqiang Zhang, Qianyu Zhao, Jiahui Chen, Siwei Pan, Yan Wang, Ruolan Zhang, Yuqi Wang, Weiwei Zhu, Mengxuan Cao, Dan Zu, Shengjie Zhang, Zhiyuan Xu, Caihong Hu, Xiangdong Cheng
Abstract
Our study not only affirm the role of GPx4 in GC progression but also highlight it as a promising target for reshaping the immune microenvironment.
Topics & Concepts
Macrophage polarizationGene knockdownCancer researchMacrophageKynurenineCancerChemistryCell biologyMedicineApoptosisBiologyInternal medicineBiochemistryIn vitroTryptophanAmino acidEpigenetics and DNA MethylationTryptophan and brain disordersImmune cells in cancer