Synthesis of Chiral α-Aryl Ketones by Photoredox/Nickel-Catalyzed Enantioconvergent Acyl Cross-Coupling with Organotrifluoroborate
Wei‐Chen Wang, Chaoren Shen, Linli Zhang, Kaiwu Dong
Abstract
Photoredox/nickel-catalyzed enantioconvergent acyl cross-coupling of carboxylic derivatives with racemic secondary organotrifluoroborate was developed for the synthesis of an enolizable chiral α-aryl ketone under mild neutral conditions. Moderate to high yields and good enantioselectivities were achieved.
Topics & Concepts
ChemistryArylKetoneCatalysisNickelOrganic chemistryCoupling (piping)Combinatorial chemistryAlkylMechanical engineeringEngineeringRadical Photochemical ReactionsCatalytic C–H Functionalization MethodsSulfur-Based Synthesis Techniques